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Avandia is a drug belonging to thiazolidinedione class and is used for anti diabetic purposes. Its official marketer is pharmaceutical firm GlaxoSmithKline. It is available as stand alone and even in combination with metformin (Avandamet). It is also known by the name of Rosiglitazone. Like any other drug belonging to its class, this drug acts by activating intracellular receptor class of PRARs (Peroxisome Proliferator activated receptors), specially PPARy. It means that it acts by increasing insulin sensitivity of the body. It is used for managing type 2 diabetes mellitus. It also reduces circulating level of insulin while also improving glycemic control.
Bio availability of Avandia is 99% and its protein binding is 99.8%. Its metabolism is hepatic type and its half life is 3-4 hours. Its molecular mass is 357.428 grams/mole. Its IUPAC (International Union of Pure and Applied Chemistry) name is 5-((4-(2-(methyl-2-pyridinylamino) ethoxy)phenyl)methyl)- 2,4-thiazolidinedione.
Avandia can also be taken along other diabetes medicines. Avandia should not be taken by people having heart problems. Avandia can even cause heart failure for these kind of people. It also causes body to retain extra fluid which may lead to weight gain and swelling. Extra fluid may even cause more heart problems. The patient should contact the doctor immediately if he experiences swelling, fluid retention, trouble in breathing, rapid increase in weight and unusual tiredness while taking Avandia. Avandia is also not recommended for those having liver problems. Also, while taking Avandia, the patient must have regular blood tests to check for liver problems. Any kind of liver disease, tiredness, dark urine, stomach problems or yellowing of skin while taking Avandia should be brought to the
doctor’s notice immediately.
Along with proper dosage, prescribed meal plan should also be followed. It is a necessity for medicine to work properly. Regular exercise and test of sugar in blood is also very necessary. It can, though be taken with or without food. Like most drugs, its dosage differs from patient to patient. This medicine can be taken alone, with insulin, with metformin, sulfonylurea and even with metformin and sulfonylurea together. Adverse effects when Avandia is taken with metformin and sulfonylurea were similar to those of monotherapy with Avandia. Missed dose should be taken immediately, but if the time for next dosage arrives, mixed dose should be skipped.
While taking Avandia, concentration of other diabetic medicines can be reduced after consultation with the doctors, as it can provide a risk of low blood sugar. Avandia also increases risk of pregnancy and should not be taken while nursing. Very rarely, Avandia has been reported to be the cause of fractures of bones and swelling in the black of the eye. At higher doses, anemia and edema become more