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Phenergan (generic name promethazine) is an antihistamine that inhibits the effects of natural histamines produced by the body. The active ingredient is promethazine HCl, a phenothiazine derivative compound used to treat allergic reactions such as sneezing, runny nose, itchy eyes, hives and skin rashes. It is also prescribed to prevent motion sickness and to alleviate post-surgical nausea and vomiting. Phenergan may also be used as a sedative. It is available in tablet form and as a suppository.

The formulation for Phenergan tablets are typically up to 50 mg of promethazine HCl mixed with magnesium stearate, lactose and methylcellulose. It also contains saccharin sodium as well as certain dyes. Rectal suppositories a combination of up to 50 mg of promethazine HCl with ascorbyl palmitate, cocoa butter, white wax and silicon dioxide.

Information you should know

When taking or administering Phenergan, any uncontrollable movements in the eyes, lips, arms, face, tongue, arms or legs are danger signs and should be reported at once to the physician. Phenergan is not to be administered to children less than two years of age because it can severely affect breathing and may cause death.

Some conditions may interact unfavorable with Phenergan. These include sleep apnea, epilepsy or other seizure disorders, glaucoma, ulcers, urinary problems, hypertension, bone marrow disorder and liver disease. Possible drug interactions may result when Phenegran is taken in combination with sedatives such as diazepam, chlordiazepoxide or triazolam or antidepressants such as amitriptyline, nortriptyline, sertraline or paroxetine. Narcotic pain medications such as morphine and oxycodone as well as Phenobarbital, secobarbital, MAO inhibitors and atropine are also medications on the watch-out list, among many others. Physicians must be privy to all the relevant drug information.

The doctor will determine whether Phenergan may be taken safely. Pregnant and breastfeeding women should consult their physicians before the medication is taken. Older subjects (over sixty) may also have more severe reactions to the medication.

Directions for taking Phenergan

Phenergan should be taken as prescribed and may be taken with or without food. Endeavor to take the correct dosage as overdosing may have serious consequences. Overdosing symptoms may include uncontrollable and severe drowsiness, dry mouth, nausea, increased sensitivity to sunlight, flushing, shallow breathing, dizziness, fainting and dilated pupils, and immediate medical should be sought.

Avoid driving and other activities that require concentration and focus right after dosing as Phenergan may impair alertness. Alcohol will also magnify the side effects of Phenergan and should be avoided.


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