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Sertraline is a selective serotonin reuptake inhibitor which is used to treat depression, obsessive compulsive disorder, panic attacks, social anxiety disorder, post-traumatic stress disorder and severe premenstrual syndrome. Antidepressant medications are used to treat depression and other mental disorders. These medications prevent suicidal thoughts and attempts. But studies have shown a small number of children or teenagers who took antidepressant experienced worsening depression, other mental/mood symptoms, or suicidal attempts. Zoloft is mainly prescribed for young adults, adults and geriatric patients.

The starting doses are generally 50 mg per day for depression and obsessive compulsive disorder. For panic disorder, the dose may be 25 mg per day. Frequently the dosages are increased to 200 mg per day. Zoloft is to be taken either in the morning or the evening. It is advised that the medicine should be continuously taken for 4 weeks to see the full effect of it. Zoloft should not be taken within 2 weeks of taking antidepressant such as Marplan, Nardil, and Parnate because when serotonin (Zoloft) combine with these medicines serious and fatal reaction may occur. Zoloft should never be combined with drug pimozide (Orap). If one is taking the oral concentrate form of Zoloft, disulfiram should be avoided.

Like all antidepressant Zoloft can trigger manic episode. If Zoloft is discontinued, withdrawal symptoms like nausea, tremors, insomnia, anxiety, and muscle pain may occur. The possible side effects are abdominal pain, agitation, constipation, decreased sex drive, diarrhea or loose stools, dizziness, dry mouth, fatigue, gas, headache, increased sweating, indigestion, nervousness, rash, sleepiness, sore throat, tingling or pins and needles, tremor, vision problems, vomiting. Many people lose one or two pounds of body weight as a result of the drug. Generally this is not a problem but can pose as a problem if due to depression one has already lost some weight. In a few people Zoloft is said to have triggered mania or hypomania.


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